This is a list of North American metropolitan areas with populations greater than one million people. This list is based on national census numbers from the United States of America, Canada, and Mexico.
| Rank | City | Population | Year | Country |
| 1 | Mexico City | 20,137,152 | 2010 | Mexico |
| 2 | New York | 18,897,109 | 2010 | USA |
| 3 | Los Angeles | 12,828,837 | 2010 | USA |
| 4 | Chicago | 9,461,105 | 2010 | USA |
| 5 | Dallas-Fort Worth | 6,371,773 | 2010 | USA |
| 6 | Philadelphia | 5,965,343 | 2010 | USA |
| 7 | Houston | 5,946,800 | 2010 | USA |
| 8 | Washington | 5,582,170 | 2010 | USA |
| 9 | Miami | 5,564,635 | 2010 | USA |
| 10 | Atlanta | 5,268,860 | 2010 | USA |
| 11 | Toronto | 5,113,149 | 2006 | Canada |
| 12 | Boston | 4,552,402 | 2010 | USA |
| 13 | Guadalajara | 4,434,252 | 2010 | Mexico |
| 14 | San Francisco-Oakland | 4,335,391 | 2010 | USA |
| 15 | Detroit | 4,296,250 | 2010 | USA |
| 16 | Riverside-San Bernardino | 4,224,851 | 2010 | USA |
| 17 | Phoenix | 4,192,887 | 2010 | USA |
| 18 | Monterrey | 4,080,329 | 2010 | Mexico |
| 19 | Montreal | 3,635,571 | 2006 | Canada |
| 20 | Seattle | 3,439,809 | 2010 | USA |
| 21 | Minneapolis-St. Paul | 3,279,833 | 2010 | USA |
| 22 | San Diego | 3,095,313 | 2010 | USA |
| 23 | St. Louis | 2,812,896 | 2010 | USA |
| 24 | Tampa-St. Petersburg | 2,783,243 | 2010 | USA |
| 25 | Baltimore | 2,710,489 | 2010 | USA |
| 26 | Puebla | 2,668,347 | 2010 | Mexico |
| 27 | Denver | 2,543,482 | 2010 | USA |
| 28 | Pittsburgh | 2,356,285 | 2010 | USA |
| 29 | Portland | 2,226,009 | 2010 | USA |
| 30 | Sacramento | 2,149,127 | 2010 | USA |
| 31 | San Antonio | 2,142,508 | 2010 | USA |
| 32 | Orlando | 2,134,411 | 2010 | USA |
| 33 | Cincinnati | 2,130,151 | 2010 | USA |
| 34 | Vancouver | 2,116,581 | 2006 | Canada |
| 35 | Cleveland | 2,077,240 | 2010 | USA |
| 36 | Kansas City | 2,035,334 | 2010 | USA |
| 37 | Las Vegas | 1,951,269 | 2010 | USA |
| 38 | Toluca | 1,846,602 | 2010 | Mexico |
| 39 | San Jose | 1,836,911 | 2010 | USA |
| 40 | Columbus | 1,836,536 | 2010 | USA |
| 41 | León | 1,792,047 | 2010 | Mexico |
| 42 | Charlotte | 1,758,038 | 2010 | USA |
| 43 | Indianapolis | 1,756,241 | 2010 | USA |
| 44 | Tijuana | 1,751,302 | 2010 | Mexico |
| 45 | Austin | 1,716,289 | 2010 | USA |
| 46 | Virginia Beach-Norfolk | 1,671,683 | 2010 | USA |
| 47 | Providence | 1,600,852 | 2010 | USA |
| 48 | Nashville | 1,589,934 | 2010 | USA |
| 49 | Milwaukee | 1,555,908 | 2010 | USA |
| 50 | Jacksonville | 1,345,596 | 2010 | USA |
| 51 | Juárez | 1,328,017 | 2010 | Mexico |
| 52 | Memphis | 1,316,100 | 2010 | USA |
| 53 | Louisville | 1,307,647 | 2010 | USA |
| 54 | Richmond | 1,258,251 | 2010 | USA |
| 55 | Oklahoma City | 1,252,987 | 2010 | USA |
| 56 | Torreón | 1,215,993 | 2010 | Mexico |
| 57 | Hartford | 1,212,381 | 2010 | USA |
| 58 | New Orleans | 1,167,764 | 2010 | USA |
| 59 | Buffalo | 1,135,509 | 2010 | USA |
| 60 | Ottawa-Gatineau | 1,130,761 | 2006 | Canada |
| 61 | Raleigh | 1,130,490 | 2010 | USA |
| 62 | Birmingham | 1,128,047 | 2010 | USA |
| 63 | Salt Lake City | 1,124,197 | 2010 | USA |
| 64 | Querétaro | 1,097,028 | 2010 | Mexico |
| 65 | Calgary | 1,079,310 | 2006 | Canada |
| 66 | Rochester | 1,054,323 | 2010 | USA |
| 67 | San Luis Potosí | 1,040,822 | 2010 | Mexico |
| 68 | Mérida | 1,035,238 | 2010 | Mexico |
| 69 | Edmonton | 1,034,945 | 2006 | Canada |